Rekombinanter CD8 alpha Antikörper

Produktnummer ABIN7127154

Dieses Kaninchen Monoklonal-Antikörper erkennt spezifisch CD8 alpha in FACS, ELISA und Coat. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für Rekombinanter CD8 alpha Antikörper (ABIN7127154)

Target: CD8 alpha (CD8A) (CD8a Molecule (CD8A))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser CD8 alpha Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), ELISA, Coating (Coat)

Produktdetails anti-CD8 alpha Antikörper

Spezifität: This MAb is specific for the 32 kDa alpha chain of human CD8, known as CD8a or CD8 alpha. CD8 is a cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8 alpha/beta) or as a homodimer (CD8 alpha/alpha). A majority of thymocytes and a subpopulation of mature T cells and NK cells express CD8a. CD8 binds to MHC class 1 and through its association with protein tyrosine kinase p56lck plays a role in T cell development and activation of mature T cells. For mature T-cells, CD4 and CD8 are mutually exclusive, so anti-CD8, generally used in conjunction with anti-CD4. It is a useful marker for distinguishing helper/inducer T-lymphocytes, and most peripheral T-cell lymphomas are CD4+/CD8-. Anaplastic large cell lymphoma is usually CD4+ and CD8-, and in T-lymphoblastic lymphoma/leukemia, CD4 and CD8 are often co-expressed. CD8 is also found in littoral cell angioma of the spleen.

Kreuzreaktivität (Details): Human and non-human primates.

Aufreinigung: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant human full-length T8 (CD8a) protein

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Known_Application: Flow Cytometry (2-4 μg/million cells), ELISA (For coating, order antibody without BSA),Optimal dilution for a specific application should be determined.

Positive_Control: HuT78 or hPBL. Tonsil

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Haltbarkeit: 24 months

Details zu CD8 alpha

Target: CD8 alpha (CD8A) (CD8a Molecule (CD8A))

Andere Bezeichnung: CD8A

Hintergrund: CD8 antigen, alpha polypeptide (p32), T8/Leu-2 T-lymphocyte differentiation antigen, Ly3, LYT3, MAL, T-cell surface glycoprotein CD8 alpha chain,CD8A (Cytotoxic / Suppressor T-Cell Marker)
Cellular localisation: Cell surface

Molekulargewicht: 32kDa

Gen-ID: 925, 85258

UniProt: P01732

Pathways: T-Zell Rezeptor Signalweg