NMI Antikörper
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- Target Alle NMI Antikörper anzeigen
- NMI (N-Myc (And STAT) Interactor (NMI))
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser NMI Antikörper ist unkonjugiert
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Applikation
- Flow Cytometry (FACS)
- Spezifität
- Nmi (for N-Myc interactor) is an interferon inducible protein that associates with multiple transcription factors, including c-Myc, n-Myc, Max, and c-Fos, which contain bHLH-ZIP, bHLH, or Zip domains. Nmi is ubiquitously expressed at low levels throughout various fetal and adult tissues and at higher levels in myeloid leukemias and cell lines overexpressing c-Myc. In addition to binding Myc proteins, Nmi also associates with the Stat family of transcription factors, where it enhances Stat-dependent transcription. Although Nmi lacks an intrinsic DNA binding or activation domain, Nmi enhances the transcriptional activity of the Stat proteins, in response to cytokine stimulation, by recruiting the Stat1 and Stat5 transcriptional coactivators, CREB-binding protein (CBP) and p300. In vitro studies indicate that Nmi, expressed in conjunction with CBP, enhances the transcriptional responsiveness of Stat5 to IL-2 stimulation five-fold over CBP alone by increasing the affinity of Stat proteins for CBP/p300.
- Kreuzreaktivität (Details)
- Human
- Aufreinigung
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogen
- Recombinant full-length human NMI protein
- Isotyp
- IgG2b
- Top Product
- Discover our top product NMI Primärantikörper
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- Applikationshinweise
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Known_Application: Flow Cytometry (1-2 μg/million cells),Optimal dilution for a specific application should be determined.
Positive_Control: HeLa or K562 cells.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Konservierungsmittel
- Azide free
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Haltbarkeit
- 24 months
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- Target
- NMI (N-Myc (And STAT) Interactor (NMI))
- Andere Bezeichnung
- NMI (NMI Produkte)
- Synonyme
- fj02e01 antikoerper, wu:fj02e01 antikoerper, NMI antikoerper, MGC108489 antikoerper, N-myc and STAT interactor antikoerper, N-myc (and STAT) interactor antikoerper, N-myc and STAT interactor L homeolog antikoerper, NMI antikoerper, Nmi antikoerper, nmi antikoerper, nmi.L antikoerper
- Hintergrund
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N myc (and STAT) interactor, N myc interactor, NMI, NMYC and STAT interactor, NMYC interactor,N myc (and STAT) Interactor / NMI
Cellular localisation: Nucleus. - Molekulargewicht
- 38kDa
- Gen-ID
- 9111, 54483
- UniProt
- Q13287
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