NMI Antikörper

Produktnummer ABIN7127126

Dieses Anti-NMI-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von NMI in FACS. Geeignet für Human.

Kurzübersicht für NMI Antikörper (ABIN7127126)

Target: NMI (N-Myc (And STAT) Interactor (NMI))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser NMI Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Produktdetails anti-NMI Antikörper

Spezifität: Nmi (for N-Myc interactor) is an interferon inducible protein that associates with multiple transcription factors, including c-Myc, n-Myc, Max, and c-Fos, which contain bHLH-ZIP, bHLH, or Zip domains. Nmi is ubiquitously expressed at low levels throughout various fetal and adult tissues and at higher levels in myeloid leukemias and cell lines overexpressing c-Myc. In addition to binding Myc proteins, Nmi also associates with the Stat family of transcription factors, where it enhances Stat-dependent transcription. Although Nmi lacks an intrinsic DNA binding or activation domain, Nmi enhances the transcriptional activity of the Stat proteins, in response to cytokine stimulation, by recruiting the Stat1 and Stat5 transcriptional coactivators, CREB-binding protein (CBP) and p300. In vitro studies indicate that Nmi, expressed in conjunction with CBP, enhances the transcriptional responsiveness of Stat5 to IL-2 stimulation five-fold over CBP alone by increasing the affinity of Stat proteins for CBP/p300.

Kreuzreaktivität (Details): Human

Aufreinigung: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant full-length human NMI protein

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise:

Known_Application: Flow Cytometry (1-2 μg/million cells),Optimal dilution for a specific application should be determined.

Positive_Control: HeLa or K562 cells.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Haltbarkeit: 24 months

Details zu NMI

Target: NMI (N-Myc (And STAT) Interactor (NMI))

Andere Bezeichnung: NMI

Hintergrund: N myc (and STAT) interactor, N myc interactor, NMI, NMYC and STAT interactor, NMYC interactor,N myc (and STAT) Interactor / NMI
Cellular localisation: Nucleus.

Molekulargewicht: 38kDa

Gen-ID: 9111, 54483

UniProt: Q13287