TIA1 Antikörper (AA 279-380)
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- Target Alle TIA1 Antikörper anzeigen
- TIA1 (TIA1 Cytotoxic Granule-Associated RNA Binding Protein (TIA1))
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Bindungsspezifität
- AA 279-380
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser TIA1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)
- Spezifität
- TIA-1 (T-cell intracytoplasmic antigen) is a cytoplasmic granule-associated protein, expressed in lymphocytes processing cytolytic potential. TIA-1 is a member of an RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15 kDa protein thought to be derived from the carboxyl terminus of the 40 kDa product by proteolytic processing. TIA1 antibody labels cytotoxic T cells and natural killer cells (NK cells). It is also expressed in T-cell lymphoma, large granular lymphocyte (LGL) leukemia and hairy cell leukemia. TIA1 expression in T-cell malignancies may help in differentiating LGL leukemia (high expression) from T-cell lymphocytosis and other T-cell diseases (low expression). TIA1 may also be used to label tumor-infiltrating lymphocytes in the study of immune response to malignancies.
- Kreuzreaktivität (Details)
- Human.
- Aufreinigung
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogen
- Recombinant human TIA1 fragment of 102 amino acid residues (aa279-380)
- Isotyp
- IgG2b
- Top Product
- Discover our top product TIA1 Primärantikörper
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- Applikationshinweise
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Known_Application: Flow Cytometry (0.5-1 μg/million cells in 0.1ml), Immunofluorescence (1-2 μg/mL), Western Blot (1-2 μg/mL for 60 minutes at RT),Optimal dilution for a specific application should be determined.
Positive_Control: HepG2, PC3 or HeLa cells. Human tonsil.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Konservierungsmittel
- Azide free
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Haltbarkeit
- 24 months
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- Target
- TIA1 (TIA1 Cytotoxic Granule-Associated RNA Binding Protein (TIA1))
- Andere Bezeichnung
- TIA1 (TIA1 Produkte)
- Synonyme
- tia1 antikoerper, 2310050N03Rik antikoerper, AI256674 antikoerper, TIA-1 antikoerper, mTIA-1 antikoerper, WDM antikoerper, TIAL1 antikoerper, TIAR antikoerper, tia-1 antikoerper, nucleolysin TIA-1 isoform p40 antikoerper, hypothetical protein antikoerper, nucleolysin TIAR antikoerper, nucleolysin tia-1 antikoerper, nucleolysin TIA-1 antikoerper, cytotoxic granule-associated RNA binding protein 1 antikoerper, TIA1 cytotoxic granule associated RNA binding protein antikoerper, TIA1 cytotoxic granule-associated RNA binding protein antikoerper, TIA1 cytotoxic granule-associated RNA binding protein L homeolog antikoerper, PTRG_10065 antikoerper, PGTG_08590 antikoerper, LOC5568274 antikoerper, CpipJ_CPIJ013665 antikoerper, VDBG_07004 antikoerper, MGYG_03339 antikoerper, Tsp_15456 antikoerper, tia1 antikoerper, Tia1 antikoerper, TIA1 antikoerper, tia1.L antikoerper
- Hintergrund
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Cytotoxic granule associated RNA binding protein 1, mTIA-1, Nucleolysin TIA1 isoform p40, p40-TIA-1, RNA binding protein TIA1, T-cell-restricted intracellular antigen-1 (TIA1), TIA-1, TIA1, TIA1 cytotoxic granule associated RNA binding protein, TIAL1, TIAR, WDM,TIA1 (T-Cell-Restricted Intracellular Antigen-1)
Cellular localisation: Cytoplasmic - Molekulargewicht
- 40kDa
- Gen-ID
- 7072, 413123
- UniProt
- P31483
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