TARBP2 Antikörper

Produktnummer ABIN7126994

Dieses Anti-TARBP2-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von TARBP2 in WB, IF und FACS. Geeignet für Human.

Kurzübersicht für TARBP2 Antikörper (ABIN7126994)

Target: TARBP2 (TAR (HIV-1) RNA Binding Protein 2 (TARBP2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TARBP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Produktdetails anti-TARBP2 Antikörper

Spezifität: TRBP2, also known as TARBP2 (trans-activation-responsive (HIV-1) RNA binding protein 2), TRBP1 or TRBP, is a nuclear protein that contains three DRBM (double-stranded RNA-binding) domains. TRBP binds between the bulge and the loop of the HIV-1 TAR RNA regulatory element and activates HIV-1 gene expression in synergy with the viral Tat protein. The third DRBM motif in the C-terminus of human TRBP2 can interact with and inhibit PKR activity, thereby increasing HIV-1 long terminal repeat (LTR) expression. In addition, TRBP2 functions as a component of a Dicer-containing complex and associates with the catalytic subunit of the RNA-induced silencing complex (RISC), namely eIF2C2. TRBP2 is essential for Dicer stability and the proper assembly of RISC. This suggests that TRBP2, in association with Dicer, plays an important role in the processing of miRNAs (microRNAs).

Kreuzreaktivität (Details): Human.

Aufreinigung: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant full-length human TARBP2 protein

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise:

Known_Application: Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), Western Blot (1-2 μg/mL), ,Optimal dilution for a specific application should be determined.

Positive_Control: MCF-7 or HeLa cells.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Haltbarkeit: 24 months

Details zu TARBP2

Target: TARBP2 (TAR (HIV-1) RNA Binding Protein 2 (TARBP2))

Andere Bezeichnung: TARBP2

Hintergrund: LOQS, Prbp, RISC loading complex subunit TARBP2, TAR (HIV 1) RNA binding protein 2, TAR RNA Binding Protein 2, TARBP2 RISC loading complex RNA binding subunit, Trans-activation-responsive RNA-binding protein, TRBP, TRBP1,TRBP2 / TARBP2
Cellular localisation: Cytoplasm. Cytoplasm > perinuclear region. Nucleus.

Molekulargewicht: 45kDa

Gen-ID: 6895, 326

UniProt: Q15633

Pathways: Regulatorische RNA Pathways, Ribonucleoprotein Complex Subunit Organization