Rekombinanter PARVG Antikörper

Produktnummer ABIN7126931

Produktdetails anti-PARVG Antikörper

Target: PARVG (Parvin, gamma (PARVG))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser PARVG Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Spezifität: The parvin family, including i±-parvin, i²-parvin and i³-parvin, link integrins and associated proteins with intracellular pathways, which regulate actin cytoskeletal dynamics and cell survival. All three family members localize to focal adhesions and function in cell adhesion, spreading, motility and survival through interactions with partners, such as integrin-linked kinase (ILK), paxillin, i±-actinin and testicular kinase 1. i±-parvin is widely expressed, with highest levels detected in the skeletal muscle, heart, liver and kidney. A complex made up of i±-parvin, ILK and the LIM protein PINCH-1 is critical for cell survival in a variety of cells, including certain cancer cells, kidney podocytes and cardiac myocytes. i²-parvin links initial integrin signals to rapid actin reorganization, thereby playing a critical role in fibroblast migration. The ILK-i³-parvin complex is essential for the establishment of cell polarity required for leukocyte migration.

Kreuzreaktivität (Details): Human.

Aufreinigung: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: GST-tagged recombinant protein corresponding to human Gamma-parvin

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Positive_Control: Jurkat cell lysate.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Haltbarkeit: 24 months

Details zu PARVG

Target: PARVG (Parvin, gamma (PARVG))

Andere Bezeichnung: PARVG (PARVG Produkte)

Synonyme: PARVG antikoerper, AI413459 antikoerper, parvin gamma antikoerper, parvin gamma S homeolog antikoerper, parvin, gamma antikoerper, PARVG antikoerper, parvg.S antikoerper, Parvg antikoerper

Hintergrund: Gamma parvin, PARVG,Gamma-parvin (PARVG)
Cellular localisation: Cytoplasm. Cell Surface.

Molekulargewicht: 37kDa

Gen-ID: 64098

UniProt: Q9HBI0