Rekombinanter PARVG Antikörper

Produktnummer ABIN7126931

Der Kaninchen Monoklonal anti-PARVG Antikörper (Klon PARVG-6312R) (ABIN7126931) detektiert spezifisch PARVG in WB und IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Rekombinanter PARVG Antikörper (ABIN7126931)

Target: PARVG (Parvin, gamma (PARVG))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser PARVG Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Klon: PARVG-6312R

Produktdetails anti-PARVG Antikörper

Verwendungszweck: Recombinant Gamma-parvin (PARVG) Antibody

Spezifität: The parvin family, including °™-parvin, æ-parvin and Á-parvin, link integrins and associated proteins with intracellular pathways, which regulate actin cytoskeletal dynamics and cell survival. All three family members localize to focal adhesions and function in cell adhesion, spreading, motility and survival through interactions with partners, such as integrin-linked kinase (ILK), paxillin, °™-actinin and testicular kinase 1. °™-parvin is widely expressed, with highest levels detected in the skeletal muscle, heart, liver and kidney. A complex made up of °™-parvin, ILK and the LIM protein PINCH-1 is critical for cell survival in a variety of cells, including certain cancer cells, kidney podocytes and cardiac myocytes. æ-parvin links initial integrin signals to rapid actin reorganization, thereby playing a critical role in fibroblast migration. The ILK-Á-parvin complex is essential for the establishment of cell polarity required for leukocyte migration.

Kreuzreaktivität (Details): Human.

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: GST-tagged recombinant protein corresponding to human Gamma-parvin

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise:

Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Positive_Control: Jurkat cell lysate.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu PARVG

Target: PARVG (Parvin, gamma (PARVG))

Andere Bezeichnung: PARVG

Hintergrund:

Gamma parvin, PARVG

Jurkat cell lysate. Raji, THP-1

Molekulargewicht: 37kDa

Gen-ID: 64098

UniProt: Q9HBI0