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MBNL3 Antikörper

Der Maus Monoklonal Anti-MBNL3-Antikörper wurde für FACS validiert. Er ist geeignet, MBNL3 in Proben von Human zu detektieren.
Produktnummer ABIN7126833

Kurzübersicht für MBNL3 Antikörper (ABIN7126833)

Target

Alle MBNL3 Antikörper anzeigen
MBNL3 (Muscleblind-Like Splicing Regulator 3 (MBNL3))

Reaktivität

  • 25
  • 2
Human

Wirt

  • 25
  • 1
Maus

Klonalität

  • 26
Monoklonal

Konjugat

  • 12
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser MBNL3 Antikörper ist unkonjugiert

Applikation

  • 15
  • 13
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Flow Cytometry (FACS)
  • Spezifität

    Pre-mRNA splicing is a critical step in the posttranscriptional regulation of gene expression. Several protein complexes are involved in proper mRNA splicing and transport. The muscleblind proteins, MBNL1, MBNL2 and MBNL3, promote inclusion or exclusion of specific exons on different pre-mRNAs by antagonizing the activity of CUG-BP and ETR-3-like factors bound to distinct intronic sites. MBNL1 and 2, which associate with expanded CUG repeats in vitro, localize to the nuclear foci in both DM1 and DM2 (myotonic dystrophy types 1 and 2), suggesting that the nuclear accumulation of mutant RNA is pathogenic in DM1, therefore implicating MBNL1 and 2 in the pathogenesis of both disorders. MBNL3, a 354 amino acid protein, inhibits expression of muscle differentiation, opposite to the function of MBNL1, which functions as a promoter of muscle differentiation. MBNL3 shows strong expression in placenta.

    Kreuzreaktivität (Details)

    Human

    Aufreinigung

    1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

    Immunogen

    Recombinant full-length human MBNL3 protein

    Isotyp

    IgG2b
  • Applikationshinweise

    Known_Application: Flow Cytometry (1-2 μg/million cells), ,Optimal dilution for a specific application should be determined.

    Positive_Control: HeLa or MCF7 cells.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Konzentration

    1.0 mg/mL

    Buffer

    Prepared in 10 mM PBS, WITHOUT BSA and Azide.

    Konservierungsmittel

    Azide free

    Lagerung

    -20 °C,-80 °C

    Informationen zur Lagerung

    Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

    Haltbarkeit

    24 months
  • Target

    MBNL3 (Muscleblind-Like Splicing Regulator 3 (MBNL3))

    Andere Bezeichnung

    MBNL3

    Hintergrund

    CHCR, Cys3His CCG1 required protein, MBLX, MBLX39, Muscleblind like protein 3, Muscleblind like splicing regulator 3, Muscleblind-like X-linked protein, Protein HCHCR, RP23-98P13.1,MBNL3
    Cellular localisation: Nucleus. Cytoplasm. Greater concentration in the nucleus. In both DM1 and DM2 patients, colocalizes with nuclear foci of retained expanded-repeat transcripts.

    Molekulargewicht

    39kDa

    Gen-ID

    55796

    UniProt

    Q9NUK0

    Pathways

    Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
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