PBX2 Antikörper

Produktnummer ABIN7126762

Dieses Anti-PBX2-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von PBX2 in ELISA, IF, IP, BP, Coat und FACS. Geeignet für Human.

Kurzübersicht für PBX2 Antikörper (ABIN7126762)

Target: PBX2 (Pre-B-Cell Leukemia Homeobox Protein 2 (PBX2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PBX2 Antikörper ist unkonjugiert

Applikation: ELISA, Immunofluorescence (IF), Immunoprecipitation (IP), Blocking Peptide (BP), Coating (Coat), Flow Cytometry (FACS)

Produktdetails anti-PBX2 Antikörper

Spezifität: Pbx 1, 2, 3 and 4 are members of the TALE (three amino acid loop extension) family of homeodomain-containing proteins. Human pre-B cell acute leukemias are frequently associated with a t(1,19)(q23,p13.3) chromosomal rearrangement, which creates a chimeric gene encoding a fusion between the E2A and Pbx 1 gene products. Pbx 2 and Pbx 3 share 92 % and 94 % respective identities with Pbx 1 over a 266 amino acid region flanking their homeobox domains, while all three proteins are quite divergent at their amino- and carboxy-termini. Two forms of Pbx 1 and Pbx 3 each differ primarily in their carboxy-termini and result from alternative mRNA splicing. Unlike other homeotic selector genes which are expressed transiently during development and differentiation, Pbx gene transcripts are ubiquitously expressed in both fetal and adult tissues and cell lines. Additionally, Pbx 2 and Pbx 3 transcripts are detected in lymphoid cells, which do not express Pbx 1. Pbx 4 expression is confined to the testis, especially to spermatocytes in the pachytene stage of the first meiotic prophase.

Kreuzreaktivität (Details): Human.

Aufreinigung: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant full-length human PBX2 protein

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise:

Known_Application: ELISA (For coating, order antibody without BSA), ,Immunoprecipitation (1-2 μg per 100-500 μg of total protein (1 mL of cell lysate)), ,Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), ,Optimal dilution for a specific application should be determined.

Positive_Control: HeLa cells. Expressed in all tissues except in cells of the B and T lineage.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Haltbarkeit: 24 months

Details zu PBX2

Target: PBX2 (Pre-B-Cell Leukemia Homeobox Protein 2 (PBX2))

Andere Bezeichnung: PBX2

Hintergrund: G17, Homeobox protein PBX2, HOX12, PBX2MHC, pre B cell leukemia homeobox 2, Pre-B-cell leukemia transcription factor 2, Protein G17,PBX2 / PRL (Transcription Factor)
Cellular localisation: Nucleus.

Molekulargewicht: 46kDa

Gen-ID: 5089, 557097

UniProt: P40425

Pathways: Skeletal Muscle Fiber Development