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PBX1 Antikörper

PBX1 Reaktivität: Human ELISA, IF, FACS, IP, BP, Coat Wirt: Maus Monoclonal unconjugated
Produktnummer ABIN7126761
  • Target Alle PBX1 Antikörper anzeigen
    PBX1 (Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1))
    Reaktivität
    • 21
    • 5
    • 5
    • 2
    • 1
    • 1
    Human
    Wirt
    • 14
    • 6
    • 1
    Maus
    Klonalität
    • 16
    • 5
    Monoklonal
    Konjugat
    • 17
    • 2
    • 1
    • 1
    Dieser PBX1 Antikörper ist unkonjugiert
    Applikation
    • 16
    • 13
    • 7
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    ELISA, Immunofluorescence (IF), Flow Cytometry (FACS), Immunoprecipitation (IP), Blocking Peptide (BP), Coating (Coat)
    Spezifität
    Pbx 1, 2, 3 and 4 are members of the TALE (three amino acid loop extension) family of homeodomain-containing proteins. Human pre-B cell acute leukemias are frequently associated with a t(1,19)(q23,p13.3) chromosomal rearrangement, which creates a chimeric gene encoding a fusion between the E2A and Pbx 1 gene products. Pbx 2 and Pbx 3 share 92 % and 94 % respective identities with Pbx 1 over a 266 amino acid region flanking their homeobox domains, while all three proteins are quite divergent at their amino- and carboxy-termini. Two forms of Pbx 1 and Pbx 3 each differ primarily in their carboxy-termini and result from alternative mRNA splicing. Unlike other homeotic selector genes which are expressed transiently during development and differentiation, Pbx gene transcripts are ubiquitously expressed in both fetal and adult tissues and cell lines. Additionally, Pbx 2 and Pbx 3 transcripts are detected in lymphoid cells, which do not express Pbx 1. Pbx 4 expression is confined to the testis, especially to spermatocytes in the pachytene stage of the first meiotic prophase.
    Kreuzreaktivität (Details)
    Human.
    Aufreinigung
    1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
    Immunogen
    Recombinant full-length human PBX1 protein
    Isotyp
    IgG2b
    Top Product
    Discover our top product PBX1 Primärantikörper
  • Applikationshinweise

    Known_Application: ELISA (For coating, order antibody without BSA), ,Immunoprecipitation (1-2 μg per 100-500 μg of total protein (1 mL of cell lysate)), ,Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), ,Optimal dilution for a specific application should be determined.

    Positive_Control: HeLa cells. Expressed in all tissues except in cells of the B and T lineage.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1.0 mg/mL
    Buffer
    Prepared in 10 mM PBS, WITHOUT BSA and Azide.
    Konservierungsmittel
    Azide free
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
    Haltbarkeit
    24 months
  • Target
    PBX1 (Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1))
    Andere Bezeichnung
    PBX1 (PBX1 Produkte)
    Hintergrund
    DKFZp686B09108, Homeobox protein PBX 1, Homeobox protein PBX1, Homeobox protein PRL, Pbx1, Pre B cell leukemia homeobox 1, Pre B cell leukemia transcription factor 1, Pre-B-cell leukemia transcription factor 1, PRL,PBX1 / PRL (Transcription Factor)
    Cellular localisation: Nucleus.
    Molekulargewicht
    86.1kDa
    Gen-ID
    5087, 557097
    UniProt
    P40424
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