OTX2 Antikörper

Produktnummer ABIN7126753

Dieses Anti-OTX2-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von OTX2 in ELISA, FACS, IP und Coat. Geeignet für Human.

Kurzübersicht für OTX2 Antikörper (ABIN7126753)

Target: OTX2 (Orthodenticle Homeobox 2 (OTX2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser OTX2 Antikörper ist unkonjugiert

Applikation: ELISA, Flow Cytometry (FACS), Immunoprecipitation (IP), Coating (Coat)

Produktdetails anti-OTX2 Antikörper

Spezifität: Transcription factors OTX1 and OTX2, two murine homologs of the Drosophila orthodenticle (OTD), show a limited amino acid sequence divergence. OTX1 and OTX2 play an important role during early and later events required for proper brain development in that they are involved in the processes of induction, specification and regionalization of the brain. OTX1 is involved in corticogenesis, sensory organ development and pituitary functions, while OTX2 is necessary earlier in development, for the correct anterior neural plate specification and organization of the primitive streak. OTX2 is also required in the early specification of the neuroectoderm, which is destined to become the fore-midbrain, and both OTX1 and OTX2 co-operate in patterning the developing brain through a dosage-dependent mechanism. A molecular mechanism depending on a precise threshold of OTX proteins is necessary for the correct positioning of the isthmic region and for anterior brain patterning. The genes which encode OTX1 and OTX2 map to human chromosomes 2p13 and 14q22.3, respectively.

Kreuzreaktivität (Details): Human. Predicted to react in Chick, Mouse, Rat, Xenopus and Zebrafish.

Aufreinigung: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant human full-lengthOTX2protein

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

Known_Application: ELISA (For coating, order antibody without BSA), ,Immunoprecipitation (1-2 μg per 100-500 μg of total protein (1 mL of cell lysate)), ,Flow Cytometry (1-2 μg/million cells), ,Optimal dilution for a specific application should be determined.

Positive_Control: HeLa cells. Human fetal gut, colon, liver or heart.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Haltbarkeit: 24 months

Details zu OTX2

Target: OTX2 (Orthodenticle Homeobox 2 (OTX2))

Andere Bezeichnung: OTX2

Hintergrund: CPHD6, Homeobox protein OTX2, MCOPS 5, MCOPS5, MGC45000, Orthodenticle 2, Orthodenticle homeobox 2, Orthodenticle homolog 2 (Drosophila), Orthodenticle homolog 2, Orthodenticle2, Otx 2, otx2,OTX2 / Orthodenticle homeobox 2 (Transcription Factor)
Cellular localisation: Nucleus.

Molekulargewicht: 71.5kDa

Gen-ID: 5015, 288655

UniProt: P32243

Pathways: Dopaminergic Neurogenesis