Rekombinanter INSM1 Antikörper (AA 81-125)

Produktnummer ABIN7126595

Dieses Kaninchen Monoklonal-Antikörper erkennt spezifisch INSM1 in IHC (f). Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für Rekombinanter INSM1 Antikörper (AA 81-125) (ABIN7126595)

Target: INSM1 (Insulinoma-Associated 1 (INSM1))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser INSM1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Produktdetails anti-INSM1 Antikörper

Bindungsspezifität: AA 81-125

Spezifität: Insulinoma-associated protein 1 (INSM1) is a developmentally regulated zinc-finger transcription factor. It localizes to the nucleus and is expressed in embryonic issues undergoing neuroendocrine differentiation. INSM1 is not expressed in normal adult tissues but can be found highly expressed in neuroendocrine tumors. INSM1 is positive in 95 % of lung small cell carcinoma and 91 % of lung large cell neuroendocrine carcinoma, compared with 75 % and 78 % with the combined panel of traditional neuroendocrine markers (synaptophysin, chromogranin, and CD56).INSM1 stains 100 % of the atypical carcinoids, typical carcinoids and paragangliomas, but only 3 % of adenocarcinomas and 4 % of squamous cell carcinomas. Therefore, INSM1 is sensitive and specific to be a single first-line pan-neuroendocrine marker.

Kreuzreaktivität (Details): Human.

Aufreinigung: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant fragment (around aa81-125) corresponding to the N-terminus of human INSM1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Positive_Control: Human pancreas or neuroendocrine tumor.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Haltbarkeit: 24 months

Details zu INSM1

Target: INSM1 (Insulinoma-Associated 1 (INSM1))

Andere Bezeichnung: INSM1

Hintergrund: IA1, Insulinoma associated protein 1 (IA1), Zinc finger protein IA1,INSM1 (Pan-Neuroendocrine Marker)
Cellular localisation: Nuclear

Molekulargewicht: 58kDa

Gen-ID: 3642, 89584

UniProt: Q01101