E2F6 Antikörper

Produktnummer ABIN7126307

Produktdetails anti-E2F6 Antikörper

Target: E2F6 (E2F Transcription Factor 6 (E2F6))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser E2F6 Antikörper ist unkonjugiert

Applikation: Immunofluorescence (IF), Flow Cytometry (FACS)

Spezifität: The human retinoblastoma gene product appears to play an important role in the negative regulation of cell proliferation. Functional inactivation of Rb can be mediated either through mutation or as a consequence of interaction with DNA tumor virus encoded proteins. Of all the Rb associations described to date, the identification of a complex between Rb and the transcription factor E2F most directly implicates Rb in regulation of cell proliferation. E2F was originally identified through its role in transcriptional activation of the adenovirus E2 promoter. Sequences homologous to the E2F binding site have been found upstream of a number of genes that encode proteins with putative functions in the G1and S phases of the cell cycle. E2F-1 is a member of a broader family of transcriptional regulators including E2F-2, E2F-3, E2F-4, E2F-5 and E2F-6, each of which forms heterodimers with a second protein, DP-1, forming an active E2F transcriptional regulatory complex.

Kreuzreaktivität (Details): Human

Aufreinigung: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant full-length human E2F6 protein

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise:

Known_Application: Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), ,Optimal dilution for a specific application should be determined.

Positive_Control: HeLa or Jurkat cells.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Haltbarkeit: 24 months

Details zu E2F6

Target: E2F6 (E2F Transcription Factor 6 (E2F6))

Andere Bezeichnung: E2F6 (E2F6 Produkte)

Synonyme: E2F-6 antikoerper, AI462434 antikoerper, E2F6b antikoerper, EMA antikoerper, E2F transcription factor 6 antikoerper, E2F6 antikoerper, E2f6 antikoerper

Hintergrund: EMA, MGC111545,E2F6
Cellular localisation: Nucleus

Molekulargewicht: 35kDa

Gen-ID: 1876, 603093

UniProt: O75461