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SMNDC1 Antikörper

Dieses Maus Monoklonal-Antikörper erkennt spezifisch SMNDC1 in FACS und IF. Er zeigt eine Reaktivität gegenüber Human.
Produktnummer ABIN7504151

Kurzübersicht für SMNDC1 Antikörper (ABIN7504151)

Target

Alle SMNDC1 Antikörper anzeigen
SMNDC1 (Survival Motor Neuron Domain Containing 1 (SMNDC1))

Reaktivität

  • 38
  • 26
  • 16
  • 5
  • 5
  • 5
  • 4
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
Human

Wirt

  • 35
  • 4
Maus

Klonalität

  • 37
  • 2
Monoklonal

Konjugat

  • 23
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser SMNDC1 Antikörper ist unkonjugiert

Applikation

  • 23
  • 15
  • 10
  • 6
  • 6
  • 5
  • 2
  • 1
  • 1
Flow Cytometry (FACS), Immunofluorescence (IF)
  • Spezifität

    SPF30 (survival of motor neuron-related-splicing factor 30), also known as SMNDC1 (survival motor neuron domain containing 1) or SMNR (SMN-related protein), is an essential splicing factor required for spliceosome assembly that belongs to the SMN family. It contains one Tudor domain with significant similarity to SMN (survival motor neuron) and is expressed in skeletal muscle, pancreas and heart, localizing to Cajal bodies and nuclear speckles. SPF30 plays an important role in spliceosome assembly and directly interacts with five U snRNPs. The loss of SPF30 causes spliceosome assembly to arrest at prespliceosomes (A complex). This supports a function for SPF30 in mediating the incorporation/recruitment of U4/U5/U6 tri-snRNP to the prespliceosome. In addition, the overexpression of SPF30 can lead to apoptosis.

    Kreuzreaktivität (Details)

    Human.

    Aufreinigung

    200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

    Immunogen

    Recombinant full-length human SMNDC1 protein

    Isotyp

    IgG2b
  • Applikationshinweise

    Positive Control: HeLa or HepG2 cells.

    Known Application: Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), ,Optimal dilution for a specific application should be determined.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Konzentration

    200 μg/mL

    Buffer

    Prepared in 10 mM PBS with 0.05 % BSA and 0.05 % azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-80 °C

    Informationen zur Lagerung

    Antibody with azide - store at 2 to 8 °C. Antibody is stable for 24 months. Non-hazardous. Also available WITHOUT BSA & azide at 1.0mg/ml.

    Haltbarkeit

    24 months
  • Target

    SMNDC1 (Survival Motor Neuron Domain Containing 1 (SMNDC1))

    Andere Bezeichnung

    SMNDC1

    Hintergrund

    30 kDa splicing factor SMNrp, MGC106917, MGC112663, SMN related protein, SMNR, SPF30, Splicing factor 30, survival of motor neuron-related, Survival motor neuron domain containing protein 1, Survival of motor neuron related splicing factor 30,SMNDC1
    Cellular localisation: Nucleus. Detected in nuclear speckles containing snRNP and in Cajal (coiled) bodies.

    Molekulargewicht

    30kDa

    Gen-ID

    10285, 632093

    UniProt

    O75940
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