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Mesothelin Antikörper (AA 273-407) (Biotin)

MSLN Reaktivität: Human IHC (f) Wirt: Maus Monoclonal Biotin
Produktnummer ABIN7126105
  • Target Alle Mesothelin (MSLN) Antikörper anzeigen
    Mesothelin (MSLN)
    Bindungsspezifität
    • 16
    • 9
    • 6
    • 5
    • 5
    • 5
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 273-407
    Reaktivität
    • 89
    • 24
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Wirt
    • 76
    • 24
    • 4
    • 1
    • 1
    Maus
    Klonalität
    • 74
    • 30
    • 2
    Monoklonal
    Konjugat
    • 69
    • 11
    • 8
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Mesothelin Antikörper ist konjugiert mit Biotin
    Applikation
    • 68
    • 51
    • 24
    • 22
    • 12
    • 11
    • 9
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
    Spezifität
    Mesothelin is a 40 kDa glycosyl-phosphatidylinositol-anchored glycoprotein cleaved from a 69 kDa precursor protein. Mesothelin immunoreactivity is high in cancers of the ovary (serous papillary, endometrioid and undifferentiated) and pancreas, with less frequent staining seen in adenocarcinomas of the endometrium, lung and stomach/esophagus. Mesothelin is one of the most sensitive markers for mesothelioma.
    Kreuzreaktivität (Details)
    Human, Mouse and Rat.
    Aufreinigung
    Antibody purified from Bioreactor Concentrate by Protein A/G and conjugated to Biotin.
    Immunogen
    Recombinant fragment (around aa 273-407) of human Mesothelin (MSLN) protein (exact sequence is proprietary)
    Isotyp
    IgG2b
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  • Applikationshinweise

    Positive Control: CAPAN-2 or HeLa cells. Lung Mesothelioma.

    Known Application: Immunohistochemistry (Formalin-fixed) (2-4 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    100 μg/mL
    Buffer
    Antibody purified from Bioreactor Concentrate by Protein A/G and conjugated to Biotin. Prepared in 10mM PBS with 0.05% BSA and 0.05% azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-80 °C
    Informationen zur Lagerung
    Antibody with azide - store at 2 to 8 °C. Antibody is stable for 24 months. Non-hazardous. Also available WITHOUT BSA & azide at 1.0mg/ml.
    Haltbarkeit
    24 months
  • Target
    Mesothelin (MSLN)
    Andere Bezeichnung
    MSLN (MSLN Produkte)
    Synonyme
    MPF antikoerper, SMRP antikoerper, MSLN antikoerper, mesothelin antikoerper, MSLN antikoerper, Msln antikoerper, LOC611363 antikoerper, LOC100524016 antikoerper
    Hintergrund
    CAK1, Megakaryocyte potentiating factor, Mesothelin, MSLN, SMR, SMRP,Mesothelin (Mesothelial Marker)
    Cellular localisation: Cell Surface and Secreted
    Molekulargewicht
    40kDa (Mature form), 69kDa (Precursor)
    Gen-ID
    10232, 408488
    UniProt
    Q13421
    Pathways
    EGFR Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Carbohydrate Homeostasis, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process
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