ZCCHC6 Antikörper

Produktnummer ABIN7121053

Dieser Kaninchen Polyklonal Antikörper erkennt spezifisch ZCCHC6 in WB, IP und ELISA. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für ZCCHC6 Antikörper (ABIN7121053)

Target: ZCCHC6 (Zinc Finger, CCHC Domain Containing 6 (ZCCHC6))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ZCCHC6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), ELISA

Produktdetails anti-ZCCHC6 Antikörper

Verwendungszweck: TUT7 antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: zinc finger, CCHC domain containing 6

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:5000, IP: 1:500-1:5000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu ZCCHC6

Target: ZCCHC6 (Zinc Finger, CCHC Domain Containing 6 (ZCCHC6))

Andere Bezeichnung: TUT7

Hintergrund:

Synonyms: Terminal uridylyltransferase 7 (TUTase 7)|Zinc finger CCHC domain-containing protein 6|TUT7|HS2|KIAA1711|ZCCHC6

Background: Uridylyltransferase that mediates the terminal uridylation of mRNAs with short(less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay(PubMed:19703396, PubMed:25480299). Involved in microRNA(miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets(PubMed:25480299). Also acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7(pre-let-7). Uridylated pre-let-7 RNA is not processed by Dicer and undergo degradation. Pre-let-7 uridylation is strongly enhanced in the presence of LIN28A(PubMed:22898984). Due to functional redundancy between ZCCHC6 and ZCCHC11, the identification of the specific role of each of these proteins is difficult.

Molekulargewicht: 171 kDa

Gen-ID: 79670

UniProt: Q5VYS8