YTHDC1 Antikörper

Produktnummer ABIN7120901

Der Kaninchen-Polyklonal Anti-YTHDC1-Antikörper wurde für WB und ELISA validiert. Er ist geeignet zum Nachweis von YTHDC1 in Proben aus Human, Maus und Ratte. }

Kurzübersicht für YTHDC1 Antikörper (ABIN7120901)

Target: YTHDC1 (YTH Domain Containing 1 (YTHDC1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser YTHDC1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-YTHDC1 Antikörper

Verwendungszweck: YTHDC1 antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: YTH domain containing 1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:200-1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu YTHDC1

Target: YTHDC1 (YTH Domain Containing 1 (YTHDC1))

Andere Bezeichnung: YTHDC1

Hintergrund:

Synonyms: YTH domain-containing protein 1|Splicing factor YT521 (YT521-B)|YTHDC1|KIAA1966|YT521

Background: Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine(m6A)-containing RNAs(PubMed:26318451, PubMed:26876937, PubMed:25242552). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability(PubMed:26318451, PubMed:25242552). Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10(PubMed:26876937). Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing(PubMed:26876937). In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing(PubMed:26876937). May also regulate alternative splice site selection(PubMed:20167602).

Molekulargewicht: 110 kDa

Gen-ID: 91746

UniProt: Q96MU7