WWP1 Antikörper

Produktnummer ABIN7120866

Dieses Anti-WWP1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von WWP1 in WB, ELISA, IP, IHC und IF. Geeignet für Human, Maus und Ratte.

Kurzübersicht für WWP1 Antikörper (ABIN7120866)

Target: WWP1 (WW Domain Containing E3 Ubiquitin Protein Ligase 1 (WWP1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser WWP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunoprecipitation (IP), Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-WWP1 Antikörper

Verwendungszweck: WWP1 antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: WW domain containing E3 ubiquitin protein ligase 1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:200-1:2000, IP: 1:200-1:1000, IF: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu WWP1

Target: WWP1 (WW Domain Containing E3 Ubiquitin Protein Ligase 1 (WWP1))

Andere Bezeichnung: WWP1

Hintergrund:

Synonyms: NEDD4-like E3 ubiquitin-protein ligase WWP1|Atrophin-1-interacting protein 5 (AIP5)|HECT-type E3 ubiquitin transferase WWP1|TGIF-interacting ubiquitin ligase 1 (Tiul1)|WW domain-containing protein 1|WWP1

Background: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1, the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF.

Molekulargewicht: 90-110 kDa

Gen-ID: 11059

UniProt: Q9H0M0