WRAP53 Antikörper
Kurzübersicht für WRAP53 Antikörper (ABIN7120809)
Target
Alle WRAP53 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Verwendungszweck
- WRAP53 antibody
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Aufreinigung
- Immunogen affinity purified
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Reinheit
- ≥95 % as determined by SDS-PAGE
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Immunogen
- WD repeat containing, antisense to TP53
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Isotyp
- IgG
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Applikationshinweise
- WB: 1:500-1:5000, IHC: 1:20-1:200, IP: 1:200-1:1000
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Handhabung
- Avoid repeated freeze / thaw cycles.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- -20°C for 12 months
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Haltbarkeit
- 12 months
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- WRAP53 (WD Repeat Containing, Antisense To TP53 (WRAP53))
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Andere Bezeichnung
- WRAP53
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Hintergrund
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Synonyms: Telomerase Cajal body protein 1|WD repeat-containing protein 79|WD40 repeat-containing protein antisense to TP53 gene (WRAP53beta)|WRAP53|TCAB1|WDR79
Background: Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes. In the telomerase holoenzyme complex, it controls telomerase localization to Cajal body. Required for delivery of TERC to telomeres during S phase and for telomerase activity. Binds small Cajal body RNAs(scaRNAs). The mRNA encoding this protein plays a critical role in the regulation of p53 expression at the post-transcriptional level, it is involved both in maintaining basal p53 mRNA levels and in p53 induction upon DNA damage.
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Molekulargewicht
- 72 kDa
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Gen-ID
- 55135
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UniProt
- Q9BUR4
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Pathways
- Telomere Maintenance
Target
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