VPS35 Antikörper

Produktnummer ABIN7120708

Produktdetails anti-VPS35 Antikörper

Target: VPS35 (Vacuolar Protein Sorting 35 (VPS35))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser VPS35 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF), ELISA

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: vacuolar protein sorting 35 homolog(S. cerevisiae)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:200-1:1000, IP: 1:200-1:1000, IF: 1:10-1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Haltbarkeit: 12 months

Details zu VPS35

Target: VPS35 (Vacuolar Protein Sorting 35 (VPS35))

Andere Bezeichnung: VPS35 (VPS35 Produkte)

Synonyme: MEM3 antikoerper, PARK17 antikoerper, vps35 antikoerper, MGC81959 antikoerper, bZ34G2.3 antikoerper, si:rp71-34g2.3 antikoerper, wu:fa66e03 antikoerper, wu:fb95c08 antikoerper, zgc:136268 antikoerper, 23.m05999 antikoerper, Mem3 antikoerper, VPS35 antikoerper, DKFZp459E1510 antikoerper, CG5625 antikoerper, DVps35 antikoerper, Dmel\\CG5625 antikoerper, Dvps35 antikoerper, dvps35 antikoerper, AI647796 antikoerper, mem3 antikoerper, VPS35, retromer complex component antikoerper, VPS35 retromer complex component L homeolog antikoerper, VPS35 retromer complex component antikoerper, vacuolar protein sorting 35 homolog (S. cerevisiae) antikoerper, vacuolar protein sorting-associated protein 35 antikoerper, vacuolar protein sorting 35 antikoerper, Vacuolar protein sorting 35 antikoerper, hypothetical protein antikoerper, VPS35 retromer complex component S homeolog antikoerper, retromer complex subunit Vps35 antikoerper, VPS35 antikoerper, vps35.L antikoerper, vps35 antikoerper, Tc00.1047053511367.170 antikoerper, Tb10.70.5460 antikoerper, BBOV_IV009740 antikoerper, CC1G_12185 antikoerper, PTRG_08682 antikoerper, CMU_017400 antikoerper, PHATR_43830 antikoerper, MCYG_00751 antikoerper, MGYG_01212 antikoerper, EHI_086580 antikoerper, EHI_002990 antikoerper, EHI_041950 antikoerper, EHI_096520 antikoerper, Bm1_44045 antikoerper, LOC100285267 antikoerper, Vps35 antikoerper, PGTG_10018 antikoerper, Tsp_09825 antikoerper, vps35.S antikoerper

Hintergrund: Synonyms:DKFZp434E1211, DKFZp434P1672, FLJ10752, FLJ13588, FLJ20388, hVPS35, Maternal embryonic 3, MEM3, Vesicle protein sorting 35, VPS35 Background:Acts as component of the retromer cargo-selective complex(CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The CSC seems to associate with the cytoplasmic domain of cargo proteins predominantly via VPS35, however, these interactions seem to be of low affinity and retromer SNX proteins may also contribute to cargo selectivity thus questioning the classical function of the CSC. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network(TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5(Probable). Required for retrograde transport of lysosomal enzyme receptor IGF2R and SLC11A2. Required to regulate transcytosis of the polymeric immunoglobulin receptor(pIgR-pIgA)(PubMed:15078903, PubMed:15247922, PubMed:20164305). Required for endosomal localization of FAM21C(PubMed:22070227). Mediates the association of the CSC with the WASH complex via FAM21(PubMed:22070227, PubMed:24980502, PubMed:24819384). Required for the endosomal localization of TBC1D5(PubMed:20923837).

Molekulargewicht: 92 kDa

Gen-ID: 55737

UniProt: Q96QK1