VPS18 Antikörper

Produktnummer ABIN7120704

Dieses Anti-VPS18-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von VPS18 in ELISA, IP, IHC, FACS und IF. Geeignet für Human, Maus und Ratte.

Kurzübersicht für VPS18 Antikörper (ABIN7120704)

Target: VPS18 (Vacuolar Protein Sorting 18 Homolog (VPS18))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser VPS18 Antikörper ist unkonjugiert

Applikation: ELISA, Immunoprecipitation (IP), Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF)

Produktdetails anti-VPS18 Antikörper

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: vacuolar protein sorting 18 homolog

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:200-1:1000, IHC: 1:50-1:500, IP: 1:200-1:1000, IF: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Haltbarkeit: 12 months

Details zu VPS18

Target: VPS18 (Vacuolar Protein Sorting 18 Homolog (VPS18))

Andere Bezeichnung: VPS18

Hintergrund: Synonyms:HVPS18, KIAA1475, PEP3, VPS18 Background:Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations(PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes(PubMed:25783203). Involved in dendrite development of Pukinje cells(By similarity).

Molekulargewicht: 110 kDa

Gen-ID: 57617

UniProt: Q9P253

Pathways: Asymmetric Protein Localization