UPF3A Antikörper
Kurzübersicht für UPF3A Antikörper (ABIN7120628)
Target
Alle UPF3A Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Verwendungszweck
- UPF3A antibody
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Aufreinigung
- Immunogen affinity purified
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Reinheit
- ≥95 % as determined by SDS-PAGE
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Immunogen
- UPF3 regulator of nonsense transcripts homolog A(yeast)
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Isotyp
- IgG
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Applikationshinweise
- WB: 1:500-1:5000, IHC:1:20-1:200,IF: 1:20-1:200
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Handhabung
- Avoid repeated freeze / thaw cycles.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- -20°C for 12 months
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Haltbarkeit
- 12 months
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- UPF3A (UPF3 Regulator of Nonsense Transcripts Homolog A (UPF3A))
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Andere Bezeichnung
- UPF3A
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Hintergrund
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Synonyms: Regulator of nonsense transcripts 3A|Nonsense mRNA reducing factor 3A|Up-frameshift suppressor 3 homolog A (hUpf3)|UPF3A|RENT3A|UPF3
Background: Involved in nonsense-mediated decay(NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex(EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex(including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. However, UPF3A is shown to be only marginally active in NMD as compared to UPF3B. Binds spliced mRNA upstream of exon-exon junctions. In vitro, weakly stimulates translation.
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Molekulargewicht
- 51 kDa
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Gen-ID
- 65110
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UniProt
- Q9H1J1
Target
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