Der Kaninchen Polyklonal Anti-UPF3A-Antikörper wurde für WB, ELISA und IHC validiert. Er ist geeignet, UPF3A in Proben von Human, Maus und Ratte zu detektieren.
UPF3A
Reaktivität: Human
Wirt: Kaninchen
Polyclonal
Alexa Fluor 680
Applikationshinweise
WB: 1:500-1:5000, IHC:1:20-1:200,IF: 1:20-1:200
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Buffer
PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
-20 °C
Informationen zur Lagerung
-20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Haltbarkeit
12 months
Target
UPF3A
(UPF3 Regulator of Nonsense Transcripts Homolog A (UPF3A))
Andere Bezeichnung
UPF3A
Hintergrund
Synonyms:HUpf3, HUPF3A, RENT3A, UPF3, UPF3A Background:Involved in nonsense-mediated decay(NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex(EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex(including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. However, UPF3A is shown to be only marginally active in NMD as compared to UPF3B. Binds spliced mRNA upstream of exon-exon junctions. In vitro, weakly stimulates translation.