USP33 Antikörper
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- Target Alle USP33 Antikörper anzeigen
- USP33 (Ubiquitin Specific Peptidase 33 (USP33))
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser USP33 Antikörper ist unkonjugiert
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Applikation
- ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
- Aufreinigung
- Immunogen affinity purified
- Reinheit
- ≥95 % as determined by SDS-PAGE
- Immunogen
- ubiquitin specific peptidase 33
- Isotyp
- IgG
- Top Product
- Discover our top product USP33 Primärantikörper
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- Applikationshinweise
- WB: 1:200-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
- Haltbarkeit
- 12 months
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- Target
- USP33 (Ubiquitin Specific Peptidase 33 (USP33))
- Andere Bezeichnung
- USP33 (USP33 Produkte)
- Synonyme
- USP33 antikoerper, VDU1 antikoerper, 9830169D19Rik antikoerper, AA409780 antikoerper, Vdu1 antikoerper, zgc:77308 antikoerper, ubiquitin specific peptidase 33 antikoerper, universal stress protein UspA antikoerper, Usp33 antikoerper, USP33 antikoerper, RR_RS17870 antikoerper, usp33 antikoerper
- Hintergrund
- Synonyms:Deubiquitinating enzyme 33, hVDU1, KIAA1097, Ubiquitin thiolesterase 33, USP33, VDU1 Background:Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in regulation of centrosome duplication by mediating deubiquitination of CCP110 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate. Involved in cell migration via its interaction with intracellular domain of ROBO1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of ROBO1. Acts as a regulator of G-protein coupled receptor(GPCR) signaling by mediating the deubiquitination of beta-arrestins(ARRB1 and ARRB2) and beta-2 adrenergic receptor(ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Mediates deubiquitination of both 'Lys-48'-and 'Lys-63'-linked polyubiquitin chains.
- Molekulargewicht
- 107 kDa
- Gen-ID
- 23032
- UniProt
- Q8TEY7
- Pathways
- Regulation of G-Protein Coupled Receptor Protein Signaling
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