USP16 Antikörper
Kurzübersicht für USP16 Antikörper (ABIN7120500)
Target
Alle USP16 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Verwendungszweck
- USP16 antibody
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Aufreinigung
- Immunogen affinity purified
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Reinheit
- ≥95 % as determined by SDS-PAGE
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Immunogen
- ubiquitin specific peptidase 16
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Isotyp
- IgG
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Applikationshinweise
- WB: 1:500-1:5000, IP: 1:500-1:5000, IHC: 1:20-1:200
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Handhabung
- Avoid repeated freeze / thaw cycles.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- -20°C for 12 months
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Haltbarkeit
- 12 months
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- USP16 (Ubiquitin Specific Peptidase 16 (USP16))
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Andere Bezeichnung
- USP16
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Hintergrund
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Synonyms: Ubiquitin carboxyl-terminal hydrolase 16|Deubiquitinating enzyme 16|Ubiquitin thioesterase 16|Ubiquitin-processing protease UBP-M|Ubiquitin-specific-processing protease 16|USP16
Background: Specifically deubiquitinates 'Lys-120' of histone H2A(H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3(H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B-and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.
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Molekulargewicht
- 94 kDa
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Gen-ID
- 10600
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UniProt
- Q9Y5T5
Target
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