USP14 Antikörper

Produktnummer ABIN7120498

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch USP14 in WB, ELISA, IF und FACS. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für USP14 Antikörper (ABIN7120498)

Target: USP14 (Ubiquitin Specific Peptidase 14 (USP14))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser USP14 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS)

Produktdetails anti-USP14 Antikörper

Verwendungszweck: USP14 antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: ubiquitin specific peptidase 14(tRNA-guanine transglycosylase)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:5000, IP: 1:500-1:5000, IF: 1:10-1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu USP14

Target: USP14 (Ubiquitin Specific Peptidase 14 (USP14))

Andere Bezeichnung: USP14

Hintergrund:

Synonyms: Ubiquitin carboxyl-terminal hydrolase 14|Deubiquitinating enzyme 14|Ubiquitin thioesterase 14|Ubiquitin-specific-processing protease 14|USP14|TGT

Background: Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation(ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Indispensable for synaptic development and function at neuromuscular junctions(NMJs).

Molekulargewicht: 52-60 kDa

Gen-ID: 9097

UniProt: P54578