USP14 Antikörper

Produktnummer ABIN7120498

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch USP14 in WB, ELISA, IF und FACS. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für USP14 Antikörper (ABIN7120498)

Target: USP14 (Ubiquitin Specific Peptidase 14 (USP14))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser USP14 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS)

Produktdetails anti-USP14 Antikörper

Verwendungszweck: USP14 antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: ubiquitin specific peptidase 14(tRNA-guanine transglycosylase)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:5000, IP: 1:500-1:5000, IF: 1:10-1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu USP14

Target: USP14 (Ubiquitin Specific Peptidase 14 (USP14))

Andere Bezeichnung: USP14

Hintergrund:

Synonyms: Ubiquitin carboxyl-terminal hydrolase 14|Deubiquitinating enzyme 14|Ubiquitin thioesterase 14|Ubiquitin-specific-processing protease 14|USP14|TGT

Background: Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation(ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Indispensable for synaptic development and function at neuromuscular junctions(NMJs).

Molekulargewicht: 52-60 kDa

Gen-ID: 9097

UniProt: P54578