Ubiquilin 1 Antikörper

Produktnummer ABIN7120456

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Ubiquilin 1 in WB, ELISA, IHC und IF. Er zeigt eine Reaktivität gegenüber Human und Ratte.

Kurzübersicht für Ubiquilin 1 Antikörper (ABIN7120456)

Target: Ubiquilin 1 (UBQLN1)

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Ubiquilin 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-Ubiquilin 1 Antikörper

Verwendungszweck: UBQLN1 antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: ubiquilin 1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:200-1:1000, IF: 1:10-1:100, IHC: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu Ubiquilin 1

Target: Ubiquilin 1 (UBQLN1)

Andere Bezeichnung: UBQLN1

Hintergrund:

Synonyms: Ubiquilin-1|Protein linking IAP with cytoskeleton 1 (PLIC-1, hPLIC-1)|UBQLN1|DA41|PLIC1

Background: UBQLN1, also known as DSK2 or Ubiquilin 1, is an ubiquitin-like proteinis contains a?N-terminal?ubiquitin-like?domain?and a C-terminal ubiquitin-associated domain.?They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation.Ubiquilin has also been shown to modulate accumulation of presenilin proteins, and is found in lesions associated with?Alzheimer's?and?Parkinson's?disease. Two transcript variants encoding different isoforms have been found for this gene. Higher levels of ubiquilin-1 in the brain decreased malformation of the APP molecule which plays a key role in triggering Alzheimers disease.Conversely, lower levels of ubiquilin-1 in the brain were associated with increased malformation of APP?(PMID: 21852239). This antibody detects 70kD band of UBQLN1.

Molekulargewicht: 71 kDa

UniProt: Q9UMX0