TRIM25 Antikörper
Kurzübersicht für TRIM25 Antikörper (ABIN7120280)
Target
Alle TRIM25 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Verwendungszweck
- TRIM25 antibody
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Aufreinigung
- Immunogen affinity purified
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Reinheit
- ≥95 % as determined by SDS-PAGE
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Immunogen
- tripartite motif-containing 25
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Isotyp
- IgG
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Applikationshinweise
- WB: 1:200-1:2000, IP: 1:200-1:2000, IF: 1:20-1:200
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Handhabung
- Avoid repeated freeze / thaw cycles.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- -20°C for 12 months
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Haltbarkeit
- 12 months
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- TRIM25 (Tripartite Motif Containing 25 (TRIM25))
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Andere Bezeichnung
- TRIM25
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Hintergrund
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Synonyms: E3 ubiquitin/ISG15 ligase TRIM25|Estrogen-responsive finger protein|RING finger protein 147|RING-type E3 ubiquitin transferase|RING-type E3 ubiquitin transferase TRIM25|Tripartite motif-containing protein 25|Ubiquitin/ISG15-conjugating enzyme TRIM25|Zinc finger protein 147|TRIM25|EFP|RNF147|ZNF147
Background: Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58. Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production of interferons in response to viral infection. Promotes ISGylation of 14-3-3 sigma(SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target organs. Mediates the ubiquitination and subsequent proteasomal degradation of ZFHX3(PubMed:22452784).
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Molekulargewicht
- 71 kDa
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Gen-ID
- 7706
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UniProt
- Q14258
Target
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