TRIM11 Antikörper

Produktnummer ABIN7120272

Dieses Anti-TRIM11-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von TRIM11 in ELISA, WB und IHC. Geeignet für Human und Maus.

Kurzübersicht für TRIM11 Antikörper (ABIN7120272)

Target: TRIM11 (Tripartite Motif Containing 11 (TRIM11))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TRIM11 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-TRIM11 Antikörper

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: tripartite motif-containing 11

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:200-1:1000, IHC: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Haltbarkeit: 12 months

Details zu TRIM11

Target: TRIM11 (Tripartite Motif Containing 11 (TRIM11))

Andere Bezeichnung: TRIM11

Hintergrund: Synonyms:BIA1, Protein BIA1, RING finger protein 92, RNF92, TRIM11, tripartite motif containing 11 Background:E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN(humanin) or HN-containing proteins through the proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses. Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression. Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain. May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle.

Molekulargewicht: 52 kDa

Gen-ID: 81559

UniProt: Q96F44