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TRAIP Antikörper

Der Kaninchen Polyklonal Anti-TRAIP-Antikörper wurde für ELISA, IHC, WB und IF validiert. Er ist geeignet, TRAIP in Proben von Human und Maus zu detektieren.
Produktnummer ABIN7120031

Kurzübersicht für TRAIP Antikörper (ABIN7120031)

Target

Alle TRAIP Antikörper anzeigen
TRAIP (TRAF Interacting Protein (TRAIP))

Reaktivität

  • 21
  • 2
  • 2
Human, Maus

Wirt

  • 16
  • 4
  • 1
Kaninchen

Klonalität

  • 18
  • 3
Polyklonal

Konjugat

  • 14
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser TRAIP Antikörper ist unkonjugiert

Applikation

  • 12
  • 9
  • 6
  • 4
  • 3
  • 2
  • 1
  • 1
  • 1
ELISA, Immunohistochemistry (IHC), Western Blotting (WB), Immunofluorescence (IF)
  • Aufreinigung

    Immunogen affinity purified

    Reinheit

    ≥95 % as determined by SDS-PAGE

    Immunogen

    TRAF interacting protein

    Isotyp

    IgG
  • Applikationshinweise

    WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:10-1:100

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

    Haltbarkeit

    12 months
  • Target

    TRAIP (TRAF Interacting Protein (TRAIP))

    Andere Bezeichnung

    TRAIP

    Hintergrund

    Synonyms:RNF206, TRIP Background:E3 ubiquitin ligase acting as a negative regulator of innate immune signaling. Inhibits activation of NF-kappa-B mediated by TNF. Negatively regulates TLR3/4-and RIG-I-mediated IRF3 activation and subsequent IFNB1 production and cellular antiviral response by promoting 'Lys-48'-linked polyubiquitination of TNK1 leading to its proteasomal degradation(By similarity)(PubMed:22945920). Involved in response to genotoxic lesions during genome replication. Promotes H2AX and RPA2 phosphorylation after replication-associated DNA damage and assists fork progression at UV-induced replication-blocking lesions during S phase(PubMed:26595769). Has also been proposed to play a role in promoting translesion synthesis by mediating the assembly of 'Lys-63'-linked poly-ubiquitin chains on the Y-family polymerase POLN in order to facilitate bypass of DNA lesions and preserve genomic integrity(PubMed:24553286). The function in translesion synthesis is controversial(PubMed:26595769).

    Molekulargewicht

    53 kDa

    Gen-ID

    10293

    UniProt

    Q9BWF2
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