TRAIP Antikörper (AA 1-204)

Produktnummer ABIN7120031

Der Kaninchen Polyklonal Anti-TRAIP-Antikörper wurde für ELISA, IHC, WB und IF validiert. Er ist geeignet, TRAIP in Proben von Human und Maus zu detektieren.

Kurzübersicht für TRAIP Antikörper (AA 1-204) (ABIN7120031)

Target: TRAIP (TRAF Interacting Protein (TRAIP))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TRAIP Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Western Blotting (WB), Immunofluorescence (IF)

Produktdetails anti-TRAIP Antikörper

Bindungsspezifität: AA 1-204

Verwendungszweck: TRAIP antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 1-204aa

Immunogen: TRAF interacting protein

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:10-1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu TRAIP

Target: TRAIP (TRAF Interacting Protein (TRAIP))

Andere Bezeichnung: TRAIP

Hintergrund:

Synonyms: E3 ubiquitin-protein ligase TRAIP|RING finger protein 206|TRAF-interacting protein|TRAIP|RNF206|TRIP

Background: E3 ubiquitin ligase acting as a negative regulator of innate immune signaling. Inhibits activation of NF-kappa-B mediated by TNF. Negatively regulates TLR3/4-and RIG-I-mediated IRF3 activation and subsequent IFNB1 production and cellular antiviral response by promoting 'Lys-48'-linked polyubiquitination of TNK1 leading to its proteasomal degradation(By similarity)(PubMed:22945920). Involved in response to genotoxic lesions during genome replication. Promotes H2AX and RPA2 phosphorylation after replication-associated DNA damage and assists fork progression at UV-induced replication-blocking lesions during S phase(PubMed:26595769). Has also been proposed to play a role in promoting translesion synthesis by mediating the assembly of 'Lys-63'-linked poly-ubiquitin chains on the Y-family polymerase POLN in order to facilitate bypass of DNA lesions and preserve genomic integrity(PubMed:24553286). The function in translesion synthesis is controversial(PubMed:26595769).

Molekulargewicht: 53 kDa

Gen-ID: 10293

UniProt: Q9BWF2