TSPAN12 Antikörper
Kurzübersicht für TSPAN12 Antikörper (ABIN7119860)
Target
Alle TSPAN12 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Verwendungszweck
- TSPAN12 antibody
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Aufreinigung
- Immunogen affinity purified
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Reinheit
- ≥95 % as determined by SDS-PAGE
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Immunogen
- tetraspanin 12
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Isotyp
- IgG
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anti-Tetraspanin 12 (TSPAN12) (AA 111-224) antibody
TSPAN12 Reaktivität: Human, Ratte, Maus WB, ELISA, IHC Wirt: Kaninchen Polyclonal unconjugated
anti-Tetraspanin 12 (TSPAN12) (AA 232-259), (C-Term) antibodyTSPAN12 Reaktivität: Human WB, IHC (p), FACS Wirt: Kaninchen Polyclonal RB22652 unconjugated
anti-Tetraspanin 12 (TSPAN12) (AA 111-224) antibodyTSPAN12 Reaktivität: Human ELISA, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
anti-Tetraspanin 12 (TSPAN12) (AA 185-234) antibodyTSPAN12 Reaktivität: Human, Ratte, Maus, Hund, Rind (Kuh), Meerschweinchen, Pferd, Kaninchen, Fledermaus, Affe, Schwein WB, IHC (p), IHC Wirt: Kaninchen Polyclonal unconjugated
anti-Tetraspanin 12 (TSPAN12) antibodyTSPAN12 Reaktivität: Human WB, IHC, FACS Wirt: Kaninchen Polyclonal unconjugated
anti-Tetraspanin 12 (TSPAN12) (AA 1-100) antibodyTSPAN12 Reaktivität: Human, Ratte ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Tetraspanin 12 (TSPAN12) (AA 179-228) antibodyTSPAN12 Reaktivität: Human, Ratte, Maus, Hund, Rind (Kuh), Meerschweinchen, Pferd, Kaninchen, Zebrafisch (Danio rerio), Fledermaus, Affe, Schwein WB Wirt: Kaninchen Polyclonal unconjugated
anti-Tetraspanin 12 (TSPAN12) (Middle Region) antibodyTSPAN12 Reaktivität: Human, Ratte, Maus, Hund WB Wirt: Kaninchen Polyclonal unconjugated
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Applikationshinweise
- WB: 1:200-1:2000
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Handhabung
- Avoid repeated freeze / thaw cycles.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- -20°C for 12 months
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Haltbarkeit
- 12 months
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- TSPAN12 (Tetraspanin 12 (TSPAN12))
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Andere Bezeichnung
- TSPAN12
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Hintergrund
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Synonyms: Tetraspanin-12 (Tspan-12)|Tetraspan NET-2|Transmembrane 4 superfamily member 12|TSPAN12|NET2|TM4SF12
Background: Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin(NDP) signal transduction. Acts in concert with norrin(NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin(CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin(NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin(CTNNB1)(By similarity). Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein(APP). Activates MMP14/MT1-MMP-dependent cleavage activity.
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Molekulargewicht
- 28 kDa
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Gen-ID
- 23554
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UniProt
- O95859
Target
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