TBC1D5 Antikörper

Produktnummer ABIN7119805

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch TBC1D5 in WB, ELISA, IP und IHC. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für TBC1D5 Antikörper (ABIN7119805)

Target: TBC1D5 (TBC1 Domain Family, Member 5 (TBC1D5))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TBC1D5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunoprecipitation (IP), Immunohistochemistry (IHC)

Produktdetails anti-TBC1D5 Antikörper

Verwendungszweck: TBC1D5 antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: TBC1 domain family, member 5

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2400, IP: 1:200-1:1000 , IHC: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu TBC1D5

Target: TBC1D5 (TBC1 Domain Family, Member 5 (TBC1D5))

Andere Bezeichnung: TBC1D5

Hintergrund:

Synonyms: TBC1 domain family member 5|TBC1D5|KIAA0210

Background: May act as a GTPase-activating protein(GAP) for Rab family protein(s). May act as a GAP for RAB7A. Can displace RAB7A and retromer CSC subcomplex from the endosomal membrane to the cytosol, at least retromer displacement seems to require its catalytic activity(PubMed:19531583, PubMed:20923837). Required for retrograde transport of cargo proteins from endosomes to the trans-Golgi network(TGN), the function seems to require its catalytic activity. Involved in regulation of autophagy(PubMed:22354992). May act as a molecular switch between endosomal and autophagosomal transport and is involved in reprogramming vesicle trafficking upon autophagy induction. Involved in the trafficking of ATG9A upon activation of autophagy. May regulate the recruitment of ATG9A-AP2-containing vesicles to autophagic membranes(PubMed:24603492).

Molekulargewicht: 89 kDa

Gen-ID: 9779

UniProt: Q92609