DR1 Antikörper

Produktnummer ABIN7119791

Der Kaninchen Polyklonal Anti-DR1-Antikörper wurde für WB, IHC, ELISA und IF validiert. Er ist geeignet, DR1 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für DR1 Antikörper (ABIN7119791)

Target: DR1 (TATA-Binding Protein-Associated Phosphoprotein (DR1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Produktdetails anti-DR1 Antikörper

Verwendungszweck: DR1 antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: down-regulator of transcription 1, TBP-binding (negative cofactor 2)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu DR1

Target: DR1 (TATA-Binding Protein-Associated Phosphoprotein (DR1))

Andere Bezeichnung: DR1

Hintergrund:

Synonyms: Protein Dr1|Down-regulator of transcription 1|Negative cofactor 2-beta (NC2-beta)|TATA-binding protein-associated phosphoprotein|DR1

Background: This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription.

Molekulargewicht: 19 kDa

Gen-ID: 1810

UniProt: Q01658