SS18L1 Antikörper

Produktnummer ABIN7119693

Dieses Anti-SS18L1-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von SS18L1 in WB und ELISA. Geeignet für Human, Maus und Ratte.

Kurzübersicht für SS18L1 Antikörper (ABIN7119693)

Target: SS18L1 (Synovial Sarcoma Translocation Gene On Chromosome 18-Like 1 (SS18L1))

Reaktivität: Human, Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SS18L1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Klon: 7A7

Produktdetails anti-SS18L1 Antikörper

Aufreinigung: Protein A+G purification

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: synovial sarcoma translocation gene on chromosome 18-like 1

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: WB: 1:1000-1:6000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Haltbarkeit: 12 months

Details zu SS18L1

Target: SS18L1 (Synovial Sarcoma Translocation Gene On Chromosome 18-Like 1 (SS18L1))

Andere Bezeichnung: CREST

Hintergrund: Synonyms:CREST, KIAA0693, LP2261, SS18 like protein 1, SS18L1, SYT homolog 1 Background:Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein(CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP(By similarity).

Molekulargewicht: 50 kDa

UniProt: O75177