SMC5 Antikörper

Produktnummer ABIN7119560

Der Kaninchen Polyklonal Anti-SMC5-Antikörper wurde für WB und ELISA validiert. Er ist geeignet, SMC5 in Proben von Human, Ratte und Maus zu detektieren.

Kurzübersicht für SMC5 Antikörper (ABIN7119560)

Target: SMC5 (Structural Maintenance of Chromosomes 5 (SMC5))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SMC5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-SMC5 Antikörper

Verwendungszweck: SMC5 antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: structural maintenance of chromosomes 5

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu SMC5

Target: SMC5 (Structural Maintenance of Chromosomes 5 (SMC5))

Andere Bezeichnung: SMC5

Hintergrund:

Synonyms: Structural maintenance of chromosomes protein 5 (SMC protein 5, SMC-5, hSMC5)|SMC5|KIAA0594|SMC5L1

Background: Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT(alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex(telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies(APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression, the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome(PubMed:26983541).

Molekulargewicht: 120-130 kDa

Gen-ID: 23137

UniProt: Q8IY18