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SATB1 Antikörper

SATB1 Reaktivität: Human, Maus, Ratte WB, ELISA, IP Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7118794
  • Target Alle SATB1 Antikörper anzeigen
    SATB1 (SATB Homeobox 1 (SATB1))
    Reaktivität
    • 69
    • 48
    • 29
    • 6
    • 5
    • 3
    • 2
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 59
    • 9
    • 1
    Kaninchen
    Klonalität
    • 50
    • 19
    Polyklonal
    Konjugat
    • 38
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SATB1 Antikörper ist unkonjugiert
    Applikation
    • 35
    • 23
    • 14
    • 14
    • 13
    • 12
    • 12
    • 11
    • 10
    • 6
    • 3
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunoprecipitation (IP)
    Aufreinigung
    Immunogen affinity purified
    Reinheit
    ≥95 % as determined by SDS-PAGE
    Immunogen
    SATB homeobox 1
    Isotyp
    IgG
    Top Product
    Discover our top product SATB1 Primärantikörper
  • Applikationshinweise
    WB: 1:500-1:2000, IP: 1:200-1:2000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
    Haltbarkeit
    12 months
  • Target
    SATB1 (SATB Homeobox 1 (SATB1))
    Andere Bezeichnung
    SATB1 (SATB1 Produkte)
    Hintergrund
    Synonyms: Background:Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma(By similarity). Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence(CSBS), at nuclear matrix-or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions(MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes(e.g. PML at the MHC-I locus) and also by recruiting corepressors(HDACs) or coactivators(HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Required for the switching of fetal globin species, and beta-and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis. Interacts with the unique region(UR) of cytomegalovirus(CMV). Alu-like motifs and SATB1-binding sites provide a unique chromatin context which seems preferentially targeted by the HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL2 and IL2RA(interleukin) in T-cells by binding to the same domain than HDAC1. Delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. Reprograms chromatin organization and the transcription profiles of breast tumors to promote growth and metastasis.
    Molekulargewicht
    100 kDa
    Gen-ID
    6304
    UniProt
    Q01826
    Pathways
    Caspase Kaskade in der Apoptose, Activated T Cell Proliferation
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