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SATB1 Antikörper

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch SATB1 in WB, ELISA und IP. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.
Produktnummer ABIN7118794

Kurzübersicht für SATB1 Antikörper (ABIN7118794)

Target

Alle SATB1 Antikörper anzeigen
SATB1 (SATB Homeobox 1 (SATB1))

Reaktivität

  • 69
  • 48
  • 29
  • 6
  • 5
  • 3
  • 2
  • 1
  • 1
Human, Maus, Ratte

Wirt

  • 59
  • 9
  • 1
Kaninchen

Klonalität

  • 50
  • 19
Polyklonal

Konjugat

  • 38
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser SATB1 Antikörper ist unkonjugiert

Applikation

  • 35
  • 23
  • 14
  • 14
  • 13
  • 12
  • 12
  • 11
  • 10
  • 6
  • 3
  • 2
  • 2
  • 2
  • 1
Western Blotting (WB), ELISA, Immunoprecipitation (IP)
  • Aufreinigung

    Immunogen affinity purified

    Reinheit

    ≥95 % as determined by SDS-PAGE

    Immunogen

    SATB homeobox 1

    Isotyp

    IgG
  • Applikationshinweise

    WB: 1:500-1:2000, IP: 1:200-1:2000

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

    Haltbarkeit

    12 months
  • Target

    SATB1 (SATB Homeobox 1 (SATB1))

    Andere Bezeichnung

    SATB1

    Hintergrund

    Synonyms: Background:Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma(By similarity). Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence(CSBS), at nuclear matrix-or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions(MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes(e.g. PML at the MHC-I locus) and also by recruiting corepressors(HDACs) or coactivators(HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Required for the switching of fetal globin species, and beta-and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis. Interacts with the unique region(UR) of cytomegalovirus(CMV). Alu-like motifs and SATB1-binding sites provide a unique chromatin context which seems preferentially targeted by the HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL2 and IL2RA(interleukin) in T-cells by binding to the same domain than HDAC1. Delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. Reprograms chromatin organization and the transcription profiles of breast tumors to promote growth and metastasis.

    Molekulargewicht

    100 kDa

    Gen-ID

    6304

    UniProt

    Q01826

    Pathways

    Caspase Kaskade in der Apoptose, Activated T Cell Proliferation
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