RBM25 Antikörper

Produktnummer ABIN7118681

Der Kaninchen-Polyklonal Anti-RBM25-Antikörper wurde für WB, ELISA und IHC validiert. Er ist geeignet zum Nachweis von RBM25 in Proben aus Maus und Human. }

Kurzübersicht für RBM25 Antikörper (ABIN7118681)

Target: RBM25 (RNA Binding Motif Protein 25 (RBM25))

Reaktivität: Maus, Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RBM25 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-RBM25 Antikörper

Verwendungszweck: RBM25 antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: RNA binding motif protein 25

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:200-1:2000, IP: 1:200-1:2000, IHC: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu RBM25

Target: RBM25 (RNA Binding Motif Protein 25 (RBM25))

Andere Bezeichnung: RBM25

Hintergrund:

Synonyms: RNA-binding protein 25|Arg/Glu/Asp-rich protein of 120 kDa (RED120)|Protein S164|RNA-binding motif protein 25|RNA-binding region-containing protein 7|RBM25|RNPC7

Background: RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site(5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7L3 promotes U1 snRNP binding to a weak 5' ss in a 5'-CGGGCA-3'-dependent manner. Binds to the exonic splicing enhancer 5'-CGGGCA-3' RNA sequence located within exon 2 of the BCL2L1 pre-mRNA. Also involved in the generation of an abnormal and truncated splice form of SCN5A in heart failure.

Molekulargewicht: 110-120 kDa

Gen-ID: 58517

UniProt: P49756