RLIM Antikörper

Produktnummer ABIN7118663

Der Kaninchen-Polyklonal Anti-RLIM-Antikörper wurde für WB, ELISA und IP validiert. Er ist geeignet zum Nachweis von RLIM in Proben aus Human, Maus und Ratte. }

Kurzübersicht für RLIM Antikörper (ABIN7118663)

Target: RLIM (Ring Finger Protein, LIM Domain Interacting (RLIM))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RLIM Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunoprecipitation (IP)

Produktdetails anti-RLIM Antikörper

Verwendungszweck: RLIM antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: ring finger protein, LIM domain interacting

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000, IP: 1:200-1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu RLIM

Target: RLIM (Ring Finger Protein, LIM Domain Interacting (RLIM))

Andere Bezeichnung: RLIM

Hintergrund:

Synonyms: E3 ubiquitin-protein ligase RLIM|LIM domain-interacting RING finger protein|RING finger LIM domain-binding protein (R-LIM)|RING finger protein 12|RING-type E3 ubiquitin transferase RLIM|Renal carcinoma antigen NY-REN-43|RLIM|RNF12

Background: E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals.

Molekulargewicht: 75 kDa

Gen-ID: 51132

UniProt: Q9NVW2