RNF41 Antikörper

Produktnummer ABIN7118659

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch RNF41 in WB und ELISA. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für RNF41 Antikörper (ABIN7118659)

Target: RNF41 (Ring Finger Protein 41 (RNF41))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RNF41 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-RNF41 Antikörper

Verwendungszweck: RNF41 antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: ring finger protein 41

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu RNF41

Target: RNF41 (Ring Finger Protein 41 (RNF41))

Andere Bezeichnung: RNF41

Hintergrund:

Synonyms: E3 ubiquitin-protein ligase NRDP1|RING finger protein 41|RING-type E3 ubiquitin transferase NRDP1|RNF41|FLRF|NRDP1

Background: Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of proinflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus(By similarity). Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin(EPO) and interleukin-3(IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages(By similarity). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PARK2 modifier that accelerates its degradation, resulting in a reduction of PARK2 activity, influencing the balance of intracellular redox state. The RNF41-PARK2 pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control(PubMed:24949970).

Molekulargewicht: 36 kDa

Gen-ID: 10193

UniProt: Q9H4P4

Pathways: SARS-CoV-2 Protein Interaktom