RNF4 Antikörper

Produktnummer ABIN7118657

Der Kaninchen Polyklonal Anti-RNF4-Antikörper wurde für ELISA und IP validiert. Er ist geeignet, RNF4 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für RNF4 Antikörper (ABIN7118657)

Target: RNF4 (Ring Finger Protein 4 (RNF4))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RNF4 Antikörper ist unkonjugiert

Applikation: ELISA, Immunoprecipitation (IP)

Produktdetails anti-RNF4 Antikörper

Verwendungszweck: RNF4 antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: ring finger protein 4

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IP: 1:200-1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu RNF4

Target: RNF4 (Ring Finger Protein 4 (RNF4))

Andere Bezeichnung: RNF4

Hintergrund:

Synonyms: E3 ubiquitin-protein ligase RNF4|RING finger protein 4|Small nuclear ring finger protein (Protein SNURF)|RNF4|SNURF

Background: E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'-and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1. Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation.

Gen-ID: 6047

UniProt: P78317

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway