RNF34 Antikörper

Produktnummer ABIN7118654

Der Kaninchen Polyklonal Anti-RNF34-Antikörper wurde für ELISA und IHC validiert. Er ist geeignet, RNF34 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für RNF34 Antikörper (ABIN7118654)

Target: RNF34 (Ring Finger Protein 34 (RNF34))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RNF34 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Produktdetails anti-RNF34 Antikörper

Verwendungszweck: RNF34 antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: ring finger protein 34

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu RNF34

Target: RNF34 (Ring Finger Protein 34 (RNF34))

Andere Bezeichnung: RNF34

Hintergrund:

Synonyms: E3 ubiquitin-protein ligase RNF34|Caspase regulator CARP1|Caspases-8 and -10-associated RING finger protein 1 (CARP-1)|FYVE-RING finger protein Momo|Human RING finger homologous to inhibitor of apoptosis protein (hRFI)|RING finger protein 34|RING finger protein RIFF|RING-type E3 ubiquitin transferase RNF34|RNF34

Background: E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis(PubMed:15069192). May mediate 'Lys-48'-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway(Ref.13). Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation(PubMed:17121812). Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN(PubMed:18382127). Mediates PPARGC1A proteasomal degradation probably through ubiquitination thereby indirectly regulating the metabolism of brown fat cells(PubMed:22064484). Possibly involved in innate immunity, through 'Lys-48'-linked polyubiquitination of NOD1 and its subsequent proteasomal degradation(PubMed:25012219).

Gen-ID: 80196

UniProt: Q969K3