ARHGEF18 Antikörper
Kurzübersicht für ARHGEF18 Antikörper (ABIN7118503)
Target
Alle ARHGEF18 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Verwendungszweck
- ARHGEF18 antibody
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Aufreinigung
- Immunogen affinity purified
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Reinheit
- ≥95 % as determined by SDS-PAGE
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Immunogen
- rho/rac guanine nucleotide exchange factor(GEF) 18
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Isotyp
- IgG
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Applikationshinweise
- WB: 1:500-1:2000, IHC: 1:20-1:200
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Handhabung
- Avoid repeated freeze / thaw cycles.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- -20°C for 12 months
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Haltbarkeit
- 12 months
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- ARHGEF18 (rho/rac Guanine Nucleotide Exchange Factor (GEF) 18 (ARHGEF18))
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Andere Bezeichnung
- ARHGEF18
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Hintergrund
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Synonyms: Rho guanine nucleotide exchange factor 18|114 kDa Rho-specific guanine nucleotide exchange factor (p114-Rho-GEF, p114RhoGEF)|Septin-associated RhoGEF (SA-RhoGEF)|ARHGEF18|KIAA0521
Background: Acts as guanine nucleotide exchange factor(GEF) for RhoA GTPases. Its activation induces formation of actin stress fibers. Also act as a GEF for RAC1, inducing production of reactive oxygen species(ROS). Does not act as a GEF for CDC42. The G protein beta-gamma(Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Required for EPB41L4B-mediated regulation of the circumferential actomyosin belt in epithelial cells(PubMed:22006950).
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Molekulargewicht
- 120-130 kDa
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Gen-ID
- 23370
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UniProt
- Q6ZSZ5
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Pathways
- Neurotrophin Signalübertragung
Target
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