RBPJ Antikörper

Produktnummer ABIN7118354

Der Maus Monoklonal anti-RBPJ Antikörper wird verwendet zum Nachweis von RBPJ in Proben von Human. Er wurde validiert für WB und ELISA.

Kurzübersicht für RBPJ Antikörper (ABIN7118354)

Target: RBPJ (Recombination Signal Binding Protein For Immunoglobulin kappa J Region (RBPJ))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser RBPJ Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Klon: 2A10

Produktdetails anti-RBPJ Antikörper

Verwendungszweck: RBPJ antibody

Aufreinigung: Protein A+G purification

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: recombination signal binding protein for immunoglobulin kappa J region

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu RBPJ

Target: RBPJ (Recombination Signal Binding Protein For Immunoglobulin kappa J Region (RBPJ))

Andere Bezeichnung: RBPJ

Hintergrund:

Synonyms: Recombining binding protein suppressor of hairless|CBF-1|J kappa-recombination signal-binding protein|RBP-J kappa (RBP-J, RBP-JK)|Renal carcinoma antigen NY-REN-30|RBPJ|IGKJRB|IGKJRB1|RBPJK|RBPSUH

Background: Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins(Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions(4 % oxygen)(PubMed:23303788).

Molekulargewicht: 60 kDa

Gen-ID: 3516

UniProt: Q06330

Pathways: Notch Signalweg, Stem Cell Maintenance, Smooth Muscle Cell Migration