RAD51D Antikörper

Produktnummer ABIN7118256

Dieses Anti-RAD51D-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von RAD51D in WB, ELISA und IHC. Geeignet für Human, Ratte und Maus.

Kurzübersicht für RAD51D Antikörper (ABIN7118256)

Target: RAD51D (RAD51 Homolog D (RAD51D))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RAD51D Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-RAD51D Antikörper

Verwendungszweck: RAD51D antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: RAD51-like 3

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000, IHC: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu RAD51D

Target: RAD51D (RAD51 Homolog D (RAD51D))

Andere Bezeichnung: RAD51D

Hintergrund:

Synonyms: DNA repair protein RAD51 homolog 4|R51H3|RAD51 homolog D|RAD51-like protein 3|TRAD|RAD51D|RAD51L3

Background: Involved in the homologous recombination repair(HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Bind to single-stranded DNA(ssDNA) and has DNA-dependent ATPase activity. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Involved in telomere maintenance. The BCDX2 subcomplex XRCC2:RAD51D can stimulate Holliday junction resolution by BLM.

Molekulargewicht: 23-25 kDa

Gen-ID: 5892

UniProt: O75771