PPP1R9B Antikörper

Produktnummer ABIN7118007

Dieses Anti-PPP1R9B-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von PPP1R9B in WB, ELISA, IHC und IP. Geeignet für Human, Ratte und Maus.

Kurzübersicht für PPP1R9B Antikörper (ABIN7118007)

Target: PPP1R9B (Protein Phosphatase 1, Regulatory Subunit 9B, Spinophilin (PPP1R9B))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PPP1R9B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)

Produktdetails anti-PPP1R9B Antikörper

Verwendungszweck: PPP1R9B antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: protein phosphatase 1, regulatory(inhibitor) subunit 9B

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu PPP1R9B

Target: PPP1R9B (Protein Phosphatase 1, Regulatory Subunit 9B, Spinophilin (PPP1R9B))

Andere Bezeichnung: PPP1R9B

Hintergrund:

Synonyms: Neurabin-2|Neurabin-II|Protein phosphatase 1 regulatory subunit 9B|Spinophilin|PPP1R9B|PPP1R6

Background: Seems to act as a scaffold protein in multiple signaling pathways. Modulates excitatory synaptic transmission and dendritic spine morphology. Binds to actin filaments(F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction. Believed to target protein phosphatase 1/PP1 to dendritic spines, which are rich in F-actin, and regulates its specificity toward ion channels and other substrates, such as AMPA-type and NMDA-type glutamate receptors. Plays a role in regulation of G-protein coupled receptor signaling, including dopamine D2 receptors and alpha-adrenergic receptors. May establish a signaling complex for dopaminergic neurotransmission through D2 receptors by linking receptors downstream signaling molecules and the actin cytoskeleton. Binds to ADRA1B and RGS2 and mediates regulation of ADRA1B signaling. May confer to Rac signaling specificity by binding to both, RacGEFs and Rac effector proteins. Probably regulates p70 S6 kinase activity by forming a complex with TIAM1(By similarity). Required for hepatocyte growth factor(HGF)-induced cell migration.

Molekulargewicht: 120-130 kDa

Gen-ID: 84687

UniProt: Q96SB3

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling