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POFUT1 Antikörper

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch POFUT1 in WB, IHC, ELISA, IP und IF. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.
Produktnummer ABIN7117981

Kurzübersicht für POFUT1 Antikörper (ABIN7117981)

Target

Alle POFUT1 Antikörper anzeigen
POFUT1 (Protein O-Fucosyltransferase 1 (POFUT1))

Reaktivität

  • 39
  • 11
  • 7
  • 4
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
Human, Maus, Ratte

Wirt

  • 39
  • 2
Kaninchen

Klonalität

  • 38
  • 2
Polyklonal

Konjugat

  • 31
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
Dieser POFUT1 Antikörper ist unkonjugiert

Applikation

  • 32
  • 24
  • 17
  • 9
  • 8
  • 7
  • 6
  • 5
  • 4
  • 2
  • 1
Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunoprecipitation (IP), Immunofluorescence (IF)
  • Aufreinigung

    Immunogen affinity purified

    Reinheit

    ≥95 % as determined by SDS-PAGE

    Immunogen

    protein O-fucosyltransferase 1

    Isotyp

    IgG
  • Applikationshinweise

    WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200, IF: 1:20-1:200

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

    Haltbarkeit

    12 months
  • Target

    POFUT1 (Protein O-Fucosyltransferase 1 (POFUT1))

    Andere Bezeichnung

    POFUT1

    Hintergrund

    Synonyms:FUT12, KIAA0180 Background:Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP-fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in NOTCH signaling. Initial fucosylation of NOTCH by POFUT1 generates a substrate for FRINGE/RFNG, an acetylglucosaminyltransferase that can then extend the fucosylation on the NOTCH EGF repeats. This extended fucosylation is required for optimal ligand binding and canonical NOTCH signaling induced by DLL1 or JAGGED1. Fucosylates AGRN and determines its ability to cluster acetylcholine receptors(AChRs).

    Molekulargewicht

    44 kDa

    Gen-ID

    23509

    UniProt

    Q9H488

    Pathways

    Notch Signalweg, SARS-CoV-2 Protein Interaktom
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