PICK antikoerper, PRKCABP antikoerper, Prkcabp antikoerper, prkcabp antikoerper, MGC131295 antikoerper, PICK1 antikoerper, DKFZp470L2127 antikoerper, protein interacting with PRKCA 1 antikoerper, protein interacting with C kinase 1 antikoerper, protein interacting with PRKCA 1 L homeolog antikoerper, PICK1 antikoerper, Pick1 antikoerper, pick1 antikoerper, pick1.L antikoerper
Hintergrund
Synonyms:PRKCABP Background:Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex, the function is competetive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor(AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression(LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function.