POLR3D
Reaktivität: Human
WB
Wirt: Kaninchen
Polyclonal
unconjugated
Applikationshinweise
WB: 1:500-1:2000
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Buffer
PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
-20 °C
Informationen zur Lagerung
-20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Haltbarkeit
12 months
Target
POLR3D
(Polymerase (RNA) III (DNA Directed) Polypeptide D, 44kDa (POLR3D))
Andere Bezeichnung
POLR3D
Hintergrund
Synonyms:BN51, BN51T Background:DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs(EBERs) induce type I interferon and NF-Kappa-B through the RIG-I pathway(By similarity).