PHACTR4 Antikörper

Produktnummer ABIN7117389

Dieses Anti-PHACTR4-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von PHACTR4 in WB, ELISA und IF. Geeignet für Human, Maus und Ratte.

Kurzübersicht für PHACTR4 Antikörper (ABIN7117389)

Target: PHACTR4 (Phosphatase and Actin Regulator 4 (PHACTR4))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PHACTR4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Produktdetails anti-PHACTR4 Antikörper

Verwendungszweck: PHACTR4 antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: phosphatase and actin regulator 4

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000, IF: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu PHACTR4

Target: PHACTR4 (Phosphatase and Actin Regulator 4 (PHACTR4))

Andere Bezeichnung: PHACTR4

Hintergrund:

Synonyms: Phosphatase and actin regulator 4|PHACTR4

Background: Regulator of protein phosphatase 1(PP1) required for neural tube and optic fissure closure, and enteric neural crest cell(ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells(ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin(COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway(By similarity).

Molekulargewicht: 71-85 kDa

Gen-ID: 65979

UniProt: Q8IZ21

Pathways: Tube Formation