PASK Antikörper

Produktnummer ABIN7117245

Dieses Anti-PASK-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von PASK in WB, ELISA, IF und IHC. Geeignet für Human, Maus und Ratte.

Kurzübersicht für PASK Antikörper (ABIN7117245)

Target: PASK (PAS Domain Containing Serine/threonine Kinase (PASK))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PASK Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC)

Produktdetails anti-PASK Antikörper

Verwendungszweck: PASK antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: PAS domain containing serine/threonine kinase

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu PASK

Target: PASK (PAS Domain Containing Serine/threonine Kinase (PASK))

Andere Bezeichnung: PASK

Hintergrund:

Synonyms: PAS domain-containing serine/threonine-protein kinase (PAS-kinase, PASKIN, hPASK)|PASK|KIAA0135

Background: Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions(oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells, however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate to respiratory regulation.

Molekulargewicht: 180 kDa

Gen-ID: 23178

UniProt: Q96RG2

Pathways: Regulation of Carbohydrate Metabolic Process