OTUD7B Antikörper

Produktnummer ABIN7117156

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch OTUD7B in ELISA, WB, IHC und IP. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für OTUD7B Antikörper (ABIN7117156)

Target: OTUD7B (OTU Domain Containing 7B (OTUD7B))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser OTUD7B Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Produktdetails anti-OTUD7B Antikörper

Verwendungszweck: OTUD7B antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: OTU domain containing 7B

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu OTUD7B

Target: OTUD7B (OTU Domain Containing 7B (OTUD7B))

Andere Bezeichnung: OTUD7B

Hintergrund:

Synonyms: OTU domain-containing protein 7B|Cellular zinc finger anti-NF-kappa-B protein (Cezanne)|Zinc finger A20 domain-containing protein 1|Zinc finger protein Cezanne|OTUD7B|ZA20D1

Background: Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections. Mediates deubiquitination of EGFR. Has deubiquitinating activity toward 'Lys-11', 'Lys-48' or 'Lys-63'-linked polyubiquitin chains. In vitro, has preference for 'Lys-11'-linked polyubiquitin chains, however such data are unsure in vivo. Hydrolyzes both linear and branched forms of polyubiquitin.

Molekulargewicht: 100 kDa

Gen-ID: 56957

UniProt: Q6GQQ9